J Integrative Medicine 2004;8:101-108

The symptoms include : • Muscle pain • Multi-joint pain without joint swelling or redness • Sore throat • Self-reported impairment in short-term memory or concentration severe enough to cause substantial reduction in previous levels of occupational, educational, social or personal activities • Changes in mood • Headaches of a new type, pattern or severity • Un-refreshing sleep • Tachycardia • Coldness of the extremities • Sweating • Pallor and sluggish pupils • Post-exertional malaise lasting more than 24 hrs. The signs include : • Low-grade fever • Non-exudative pharyngitis • Palpable or tender lymph nodes